Magali Saint-Geniez, Ph.D.

Profile

Dr. Magali Saint-Geniez, PhD, is an Investigator working in the D’Amore lab. Before joining the Schepens Eye Research Institute, Dr. Saint-Geniez trained as a graduate student with Dr. Yves Audigier at the INSERM U397 in Toulouse, France. There, she developed her passion for vascular biology, focusing more specifically on eye development and pathologies. Today, her current research interests are concentrated on the role of VEGF in the development and survival of the choroidal vessels. She is also investigating the non-vascular functions of VEGF in the eye, on lens development and survival of adult retinal neurons. Finally, she is characterizing the phenotype of a transgenic mice generated by the D’Amore Lab which features are similar to age-dependent macular degeneration.

Publications

1. Maharaj, A. S., Walshe, T. E., Saint-Geniez, M., Venkatesha, S., Maldonado, A. E., Himes, N. C., Matharu, K. S., Karumanchi, S. A., and D'Amore, P. A. (2008) VEGF and TGF-{beta} are required for the maintenance of the choroid plexus and ependyma. The Journal of Experimental Medicine

2. Bryan, B. A., Walshe, T. E., Mitchell, D. C., Havumaki, J. S., Saint-Geniez, M., Maharaj, A. S., Maldonado, A. E., and D'Amore, P. A. (2007) Coordinated Vascular Endothelial Growth Factor Expression and Signaling During Skeletal Myogenic Differentiation. Mol Biol Cell

3. Saint-Geniez, M., Maldonado, A. E., and D'Amore, P. A. (2006) VEGF expression and receptor activation in the choroid during development and in the adult. Investigative Ophthalmology & Visual Science 47, 3135-3142

4. Maharaj, A. S., Saint-Geniez, M., Maldonado, A. E., and D'Amore, P. A. (2006) Vascular endothelial growth factor localization in the adult. The American Journal of Pathology 168, 639-648

5. Cursiefen, C., Chen, L., Saint-Geniez, M., Hamrah, P., Jin, Y., Rashid, S., Pytowski, B., Persaud, K., Wu, Y., Streilein, J. W., and Dana, R. (2006) Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision. Proceedings of the National Academy of Sciences of the United States of America 103, 11405-11410

6. Saint-Geniez, M., and D'Amore, P. A. (2004) Development and pathology of the hyaloid, choroidal and retinal vasculature. The International Journal of Developmental Biology 48, 1045-1058

7. Lutty, G. A., Chan-Ling, T., Phelps, D. L., Adamis, A. P., Berns, K. I., Chan, C. K., Cole, C. H., D'Amore, P. A., Das, A., Deng, W. T., Dobson, V., Flynn, J. T., Friedlander, M., Fulton, A., Good, W. V., Grant, M. B., Hansen, R., Hauswirth, W. W., Hardy, R. J., Hinton, D. R., Hughes, S., McLeod, D. S., Palmer, E. A., Patz, A., Penn, J. S., Raisler, B. J., Repka, M. X., Saint-Geniez, M., Shaw, L. C., Shima, D. T., Smith, B. T., Smith, L. E., Tahija, S. G., Tasman, W., and Trese, M. T. (2006) Proceedings of the Third International Symposium on Retinopathy of Prematurity: an update on ROP from the lab to the nursery (November 2003, Anaheim, California). Molecular Vision 12, 532-580

8. Saint-Geniez, M., Argence, C. B., Knibiehler, B., and Audigier, Y. (2003) The msr/apj gene encoding the apelin receptor is an early and specific marker of the venous phenotype in the retinal vasculature. Gene Expr Patterns 3, 467-472

9. Le Gat, L., Gogat, K., Bouquet, C., Saint-Geniez, M., Darland, D., Van Den Berghe, L., Marchant, D., Provost, A., Perricaudet, M., Menasche, M., and Abitbol, M. (2003) In vivo adenovirus-mediated delivery of a uPA/uPAR antagonist reduces retinal neovascularization in a mouse model of retinopathy. Gene Therapy 10, 2098-2103

10. Darland, D. C., Massingham, L. J., Smith, S. R., Piek, E., Saint-Geniez, M., and D'Amore, P. A. (2003) Pericyte production of cell-associated VEGF is differentiation-dependent and is associated with endothelial survival. Developmental Biology 264, 275-288

11. Saint-Geniez, M., Masri, B., Malecaze, F., Knibiehler, B., and Audigier, Y. (2002) Expression of the murine msr/apj receptor and its ligand apelin is upregulated during formation of the retinal vessels. Mechanisms of Development 110, 183-186