Research Stories

Pablo Argüeso, Ph.D.

Carbohydrates have been traditionally considered only as sources of energy for the living organism. However, during the last few years, it has become evident that carbohydrates also play important roles in determining cell function.

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Dong Feng Chen, M.D., Ph.D.

The optic nerve is a cable of nerve fibers that carry electrical impulses, containing visual information, from the eye to the brain. In adult mammals, any damage to the optic nerve caused by injury or disease tends to be permanent

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Kin-Sang (Anson) Cho, Ph.D.

The research of Dr. Kin-Sang (Anson) Cho has been focused on why neurons in the  Central Nervous System (CNS) cannot re-grow in adult mammals. Visual system has been used as a model to study CNS regeneration. The expression pattern of Bcl-2 had been shown to correlate to the decline of intrinsic growth ability of retinal ganglion cells (CNS neurons inside retina) during development. In addition, he has demonstrated that over-expressing Bcl-2 could maintain the intrinsic growth ability over growth-inhibitory substrates in culture.

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Patricia A. D'Amore, Ph.D., M.B.A.

Conventional anti-cancer treatment has generally utilized chemotherapy. This type of treatment uses relatively non-specific agents that target growing cells. In contrast, the anti-angiogenic therapies should target only the growing blood vessels and therefore should have many fewer side effects

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Reza Dana, M.D., M.P.H., M.Sc.

Inflammation is one of the most common, and evolutionarily conserved, responses in the body. Injury (mechanical or chemical), infection, surgery, toxin exposure, allergy, growth of many cancers, etc, all lead to inflammation.

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Darlene A. Dartt, Ph.D.

The Institute began its collaboration with the Department of Defense (DoD) in the 1990s, thanks to the hard work of Trustee Dr. Donald Korb, who was able to interest the Massachusetts congressional delegation in the research conducted at the Institute

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François Delori, Ph.D.

Dr. Delori has pioneered novel imaging techniques of the retina and has developed advanced optical techniques to study the role of lipofuscin and melanin pigments in the retinal pigmented epithelium as well as new ways to measure the distribution of macular pigment in the neural retina

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Neena B. Haider, Ph.D.

Our long-term goal is to identify and evaluate genetic determinants underlying retinal diseases and develop appropriate therapeutic interventions to prevent and treat the blindness associated with these disorders. 

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Ilene K. Gipson, Ph.D.

The ocular surface is the layer of cells at the front of the eye – those cells that come in contact with the outside world.

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Meredith Gregory-Ksander, Ph.D.

There are many different types of eye infections – viral, bacterial, fungal, and amoebic. These infections can affect different parts of the eye

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Tatjana C. Jakobs, M.D.

Since 2004, Tatjana C. Jakobs, M.D. has focused her research on glaucoma, a group of eye diseases in which vision loss is caused by damage to the optic nerve. For this particular project, Dr. Jakobs has worked in cooperation with the laboratory of Dr. Simon John at the Jackson Laboratory in Bar Harbor, ME. This collaborative project started with a survey of ganglion cells in a mouse model of inherited glaucoma (DBA/2J), with a goal of finding out whether there is a differential sensitivity between ganglion cell types to glaucomatous degeneration.

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Bruce Ksander, Ph.D.

Dr. Bruce Ksander's research is directed at three areas: (i) the mechanisms that establish and maintain immune privilege within the eye, (ii) regulation of immunity to cornea allografts, and (iii) initiating immunity against ocular tumors.

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Kameran Lashkari, M.D.

The human eye is extremely vulnerable to direct laser injury and maintaining good vision is an important determinant in success of military operations, and even survival of military personnel in theatre.

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Richard H. Masland, Ph.D.

Work in this laboratory concerns the normal cell biology of the neural retina, and its disorders.

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Eli Peli, O.D.

Dr. Peli's principal research interests are image processing in relation to visual function and clinical psychophysics in low vision rehabilitation, image understanding and evaluation of display-vision interaction.

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Magali Saint-Geniez, Ph.D.

Dr. Magali Saint-Geniez is a research scientist specializing in Ophthalmology. She conducted her graduate studies at the University of Toulouse III, France, and was awarded a competitive Training Grant from the French Associate and Amblyopia (AFAU). Her thesis project focused on the determination of the functions of a new G protein-coupled receptor, msr/apj, and its ligand, Apelin, during physiological and pathological angiogenesis.

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David Sullivan, Ph.D.

Sex and sex steroid hormones are critical factors in the regulation of ocular surface tissues, as well as in the pathogenesis of dry eye syndromes...

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Russell L. Woods, Ph.D.

Visual Impairment

Central vision impairment (the most common visual impairment in "western" countries due to the prevalence of age-related macular degeneration) causes problems with reading, face recognition and watching television and movies.Dr Woods has investigated factors that impair might reading performance such as having a difference in the vision between the two eyes, how people read with optical magnifiers and he has evaluated the potential benefits of some methods for the electronic display of reading material. Electronic images, whether television, video or DVD, are a common source of entertainment and information. So, Dr Woods is involved in studies that are evaluating methods of modifying the appearance of electronic images from television etc., in the hope that visually-impaired people will more easily gain information from the images, thereby increasing their enjoyment of electronic media.

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Michael Young, Ph.D.

During the last 5 years, work in my lab has established that neural stem or progenitor cells overcome the barrier to morphological integration present in the mature mammalian retina.

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James Zieske, Ph.D.

Upon wounding of the epithelium, the epithelial cells must somehow cover and repopulate the wound site and restore its barrier function.

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Lotfi B. Merabet, O.D., Ph.D., M.P.H.

 

Lotfi B. Merabet, O.D., Ph.D., M.P.H. is an optometrist-scientist and a member of the research faculty in the Vision Rehabilitation Service at Massachusetts Eye and Ear.  He is active in research relating to individuals' adaptations to loss of sight and profound blindness.

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