Dr. D'Amore's anti-angiogenesis drug study featured in Harvard's Focus

Growth Factor’s Protection of Eye Shows Dark Side of Anti-angiogenesis Drugs

A molecule better known for pathologic promotion of leaky new blood vessels in tumors and eye diseases also protects vision, according to a study of vascular endothelial growth factor (VEGF) in healthy adult mice. The study from the lab of Patricia D’Amore , including first author Magali Saint-Geniez, appears in the November PLoS One. If the findings hold true in people, they suggest a possible risk to anti-VEGF therapy and may warrant clinical precautions such as careful monitoring or a different follow-up regimen, with lower anti-VEGF doses in the meantime.

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