Faculty
Sharmila Masli
Sharmila Masli
Assistant Scientist
617-912-0254
FAX: 617-912-0101
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Education
1986 B.Sc University of Bombay, Bombay India Microbiology
1987 D.C.A. Sophia College, Bombay, India Clinical Analysis
1994 M.S. Northeastern University, Boston Medical Lab. Science
1997 Ph.D. Northeastern University, Boston Biomedical Sciences
(Immunology)
1997 Post-Doctoral Fellow Schepens Eye Research Institute,
Boston
2000 - 2006 Investigator Schepens Eye Research Institute,
Boston, USA.
2006 - Assistant Scientist
Research
Program
It is now known that various cells and molecules in the
eye contribute to the unique ocular microenvironment, which
directs the immune response by influencing APCs. However,
the molecular mechanisms that allow eye-derived APCs to
bring about such a carefully regulated immune response are
not clearly understood. In my current research project we
have successfully employed DNA microarray technology to
identify genes uniquely expressed (up or down regulated)
when conventional APCs are exposed to molecules likely to
be found in the ocular environment. This method has allowed
a comprehensive analysis of the transcriptional program
of cells that represent eye-derived APCs, and has provided
information on expression of various genes so far not known
to be directly related to ACAID. By studying the significance
of selected genes in inducing the unique ocular immune response,
novel immunologic mechanisms displayed by eye-derived APCs
are being explored. Such an approach will open up a broad
range of mechanistic possibilities and their systematic
evaluation would clearly enhance our understanding of the
ocular immune and inflammatory processes.

